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The ends of a large RNA molecule are necessarily close

TitleThe ends of a large RNA molecule are necessarily close
Publication TypeJournal Article
Year of Publication2010
AuthorsYoffe, AM, Prinsen, P, Gelbart, WM, Ben-Shaul, A
JournalNucleic acids research
Paginationgkq642
Abstract

We show on general theoretical grounds that the two ends of single-stranded (ss) RNA molecules (consisting of roughly equal proportions of A, C, G and U) are necessarily close together, largely independent of their length and sequence. This is demonstrated to be a direct consequence of two generic properties of the equilibrium secondary structures, namely that the average proportion of bases in pairs is∼ 60% and that the average duplex length is∼ 4. Based on mfold and Vienna computations on large numbers of ssRNAs of ...

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