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Exploiting fluorescent polymers to probe the self-assembly of virus-like particles

TitleExploiting fluorescent polymers to probe the self-assembly of virus-like particles
Publication TypeJournal Article
Year of Publication2011
AuthorsCadena-Nava, RD, Hu, Y, Garmann, RF, Ng, B, Zelikin, AN, Knobler, CM, Gelbart, WM
JournalThe Journal of Physical Chemistry B
Volume115
Pagination2386–2391
Abstract

The inside surfaces of the protein shells of many viruses are positively charged, therebyenhancing the self-assembly of capsid proteins around their (oppositely charged) RNAgenome. These proteins have been shown to organize similarly around a variety ofnonbiological, negatively charged, polymers, for example, poly (styrene sulfonate)(PSS),forming virus-like particles (VLPs). We have demonstrated recently that the VLPs formedfrom cowpea chlorotic mottle virus (CCMV) capsid protein increase in size (from T= 2 to T=...

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