Multishell structures of virus coat proteins
|Title||Multishell structures of virus coat proteins|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Prinsen, P, van der Schoot, P, Gelbart, WM, Knobler, CM|
|Journal||The Journal of Physical Chemistry B|
Under conditions of low ionic strength and a pH ranging between about 3.7 and 5.0,solutions of purified coat proteins of cowpea chlorotic mottle virus (CCMV) form sphericalmultishell structures in the absence of viral RNA. The outer surfaces of the shells in thesestructures are negatively charged, whereas the inner surfaces are positively charged due to a disordered cationic N-terminal domain of the capsid protein, the arginine-rich RNA-binding motif that protrudes into the interior. We show that the main forces stabilizing these ...