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Multishell structures of virus coat proteins

TitleMultishell structures of virus coat proteins
Publication TypeJournal Article
Year of Publication2010
AuthorsPrinsen, P, van der Schoot, P, Gelbart, WM, Knobler, CM
JournalThe Journal of Physical Chemistry B
Volume114
Pagination5522–5533
Abstract

Under conditions of low ionic strength and a pH ranging between about 3.7 and 5.0,solutions of purified coat proteins of cowpea chlorotic mottle virus (CCMV) form sphericalmultishell structures in the absence of viral RNA. The outer surfaces of the shells in thesestructures are negatively charged, whereas the inner surfaces are positively charged due to a disordered cationic N-terminal domain of the capsid protein, the arginine-rich RNA-binding motif that protrudes into the interior. We show that the main forces stabilizing these ...

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