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Physical chemistry of DNA viruses

TitlePhysical chemistry of DNA viruses
Publication TypeJournal Article
Year of Publication2009
AuthorsKnobler, CM, Gelbart, WM
JournalAnnual review of physical chemistry

The relative simplicity of viruses makes it possible to apply generic physical approaches to 
the understanding of their structure and function. We focus here on viruses that have double-
stranded (ds) DNA genomes that are enclosed in a protein container called the capsid. Their 
structures are now known in precise detail from cryo-electron microscopy. dsDNA is a stiff, 
highly charged polymer, and typical viral DNAs have contour lengths 1000 times longer than 
the radius of the capsid into which they are introduced in the assembly process, which is ...

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