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Rescue of infectious particles from preassembled alphavirus nucleocapsid cores

TitleRescue of infectious particles from preassembled alphavirus nucleocapsid cores
Publication TypeJournal Article
Year of Publication2011
AuthorsSnyder, JE, Azizgolshani, O, Wu, B, He, Y, Lee, ACheun, Jose, J, Suter, DM, Knobler, CM, Gelbart, WM, Kuhn, RJ
JournalJournal of virology
Volume85
Pagination5773–5781
Abstract

ABSTRACT Alphaviruses are small, spherical, enveloped, positive-sense, single-stranded, RNA viruses responsible for considerable human and animal disease. Using microinjection of preassembled cores as a tool, a system has been established to study the assembly and budding process of Sindbis virus, the type member of the alphaviruses. We demonstrate the release of infectious virus-like particles from cells expressing Sindbis virus envelope glycoproteins following microinjection of Sindbis virus nucleocapsids purified from the ...

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