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A sequential folding model predicts length-independent secondary structure properties of long ssRNA

TitleA sequential folding model predicts length-independent secondary structure properties of long ssRNA
Publication TypeJournal Article
Year of Publication2011
AuthorsFang, LTai, Yoffe, AM, Gelbart, WM, Ben-Shaul, A
JournalThe Journal of Physical Chemistry B
Volume115
Pagination3193–3199
Abstract

We introduce a simple model for folding random-sequence RNA molecules, arguing that it provides a direct route to predicting and rationalizing several average properties of RNA secondary structures. The first folding step involves identifying the longest possible duplex, thereby dividing the molecule into a pair of daughter loops. Successive steps involve identifying similarly the longest duplex in each new pair of daughter loops, with this process proceeding sequentially until the loops are too small for a viable duplex to form....

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