Hello all,At journal club this thursday, we look at the encapsulation of Quantum Dots into Viral capsids.A PDF version of the paper is available at http://dx.doi.org/10.1021/nl061165u .See you thursday,Ajay

Hello all,At tomorrow's unconventional journal club we will have a reading, followed by discussion, of a really short 1956 classic by Watson and Crick entitled "Structure of Small Viruses". Bill has offered to lead the discussion and share his historical insights.Although not necessary, you are welcome to read the paper ahead of time. The PDF reprint is available here: http://www.nature.com/nature/journal/v177/n4506/pdf/177473a0.pdfBest,Ajay

Hello all,Hope you had a relaxing long weekend. Here's a paper to get back into work mode (speaking for myself). This paper deals with possible stable intermediates formed during the nucleation of a CCMV virus, with possible implications to the RNA and polymer-encapsulation projects.PDFs are available at: http://dx.doi.org/10.1016/j.jmb.2003.10.059See you all tomorrow,Ajay

Hello all,In line with the last journal club (which discussed the role of pH and infectivity of an enveloped virus), Mauricio has suggest the following paper looking at correlations between swelling and infectivity in CCMV.The paper is titled "Virion swelling is not required for cotranslational disassembly of cowpea chlorotic mottle virus in vitro".Abstract and PDF reprint can be found at: http://jvi.asm.org/cgi/content/abstract/71/6/4296.See you on thursday,Ajay

Dear virus enthusiasts,This week, we shall discuss a paper suggested by Odisse which investigates the effect of pH on the infectivity of Sindbis virus.PDFs can be found here: http://dx.doi.org/10.1016/j.virol.2004.03.046(please note the group website download area is not working due to a disk error that Max will fix when possible.)See you all on thursday,Ajay

Hello everyone,

The heated discussion on the molecular interpretation of osmotic effects
that were inspired by last week's paper will continue this week at
journal club.

Those who could not make it last week, are invited to join in the
discussion this week since we barely got to the subject matter in the
paper last time.

"Osmotic Stress for the Direct Measurement of Intermolecular Forces"
by Parsegian et al.
http://dx.doi.org/10.1016/0076-6879(86)27032-9

Best,

Ajay

Hello all,The corrected link to this week's online article is below:http://dx.doi.org/10.1016/0076-6879(86)27032-9Best,Ajay

Hello all,We have been talking a lot about the steps in viral RNA replication. In keeping with this theme, we will look at a paper from the prolific Ahlquist virus research lab at Wisconsin. Its a mini-review that talks about"Host Factors in Positive-Strand RNA Virus Genome Replication."(Journal of Virology, August 2003, p. 8181-8186, Vol. 77, No. 15)PDFs can be found at:http://jvi.asm.org/cgi/content/full/77/15/8181orhttp://virus.chem.ucla.edu/easyfile/file.php?show=20060508222422372As usual, see you there with ideas and lunchboxes...Ajay

Hello all,Sorry this message is a few hours later than it should be. The journal club discussion this week will be directed towards Odisse's project - the paper investigates, in the context of Sindbis virus, the "In Vitro Assembly of Alphavirus Cores by Using Nucleocapsid Protein Expressed in Escherichia coli".PDFs at:http://jvi.asm.org/cgi/content/full/73/7/5309http://virus.chem.ucla.edu/easyfile/file.php?show=20060501212756938See you on thursday at 1:30pm at Bill's office,Ajay

We shall continue the discussion from Brownbag #25 with particular focus on how Replicases operate and the molecular mechanism behind the evolution seen in transfer experiments.See you on thursday!Ajay